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Hypopituitary Dwarfism
Hypopituitary Dwarfism Is Due to Growth Hormone Deficiency

From Mary Kugler, R.N., for About.com

Updated: January 23, 2009

About.com Health's Disease and Condition content is reviewed by our Medical Review Board

Munchkins in The Wizard of Oz

Munchkins sing in The Wizard of Oz

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Before Warner Bros. sent out its worldwide casting call in 1939 for "little people" for its new movie, The Wizard of Oz, most of the 120 men and women who showed up to audition had never seen someone else who -- like them -- had hypopituitary dwarfism. Those with hypopituitary dwarfism appear "normal" and proportionate, but only stand at about 4-feet tall. At the time, a person who looked this way was called a "midget" (a term now considered offensive and derogatory).

The Cause of Hypopituitary Dwarfism: Uncovered

Since that time, scientists have discovered that this condition of proportionate short stature is usually caused by a deficiency of growth hormone. It may be present from birth due to an abnormal pituitary gland (the gland that makes growth hormone) or may be part of a syndrome. It may also be acquired from brain injury, brain infections, or other diseases.

Today, the condition is known as growth hormone deficiency, hypopituitary dwarfism, or hypopituitarism.

Hypopituitary Dwarfism Is Difficult to Diagnose

During the first two years of life, a child with growth hormone deficiency may grow at a normal rate. As the child becomes older, however, parents may notice that their child does not seem to be growing properly. The child is small compared to other kids his age and may look younger than them.

A child who grows less than 2 inches per year, or who is only as tall as children two or more years younger, should be evaluated by a physician for growth hormone deficiency after other possible causes (such as hypothyroidism) have been ruled out. Testing for growth hormone deficiency is done by stimulating the body to produce the hormone and then measuring how much hormone is actually released.

Treatment Available

Growth hormone deficiency is treated by injections of a growth hormone preparation such as Humatrope (somatropin). A child may receive daily or weekly injections. The child's growth rate increases soon after the injections are started. The treatment continues over several years until the child's maximum growth potential is achieved. Most children will reach an "acceptable" adult height.

The average adult height for someone with untreated severe growth hormone deficiency is 4 feet, 8 inches in men and 4 feet, 3 inches in women.

Sources:

"Disorders of Growth." Resources. Human Growth Foundation. 18 Jan 2009

Levy, Richard. "Growth Hormone Deficiency in Children." Disorders. 02 Jan 2009. The Magic Foundation. 18 Jan 2009

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