Some of these drugs are completely new. Others are existing drugs seeking approval for a new use. Some are the first drug proposed to treat a particular condition; others would add to treatments already available. Some of the drugs are only known by their chemical names on this list. Internet links for more information are provided where available.
(+/-)-7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid (product name: Biomed 101)
Treatment of vascular leak syndrome caused by interleukin-2 therapy
Date designated: 4/21/2003
BioMedicines, Inc.
2000 Powell Street, Suite 1640
Emeryville, CA 94608
(R)-N-[2-(6-chloro-methoxy-1H-indol-3yl)propyl]acetamide
Treatment of neuroleptic-induced tardive dyskinesia in schizophrenia patients
Date designated: 7/3/2003
Phase 2 Discovery, Inc.
3130 Highland Ave., Third Floor
Cincinnati, OH 45219
1,1'-[1,4-phenylenebis(methylene)-bis-1,4,8,11-tetraazacyclotetradecan
For use with filgrastim to improve stem cell (bone marrow) transplantation
Date designated: 7/10/2003
AnorMED Inc.
200 - 20353 64th Avenue
Langley, BC
Canada V2Y 1N5
2',3',5'-tri-o-acetyluridine
Treatment of mitochondrial disease
Date designated: 1/3/2003
RepliGen Corporation
41 Seyon Street
Building 1, Suite 100
Waltham, MA 02453
2-(3-diethylaminopropyl)-8,8-dipropyl-2-azaspiro [4,5[ decan dimaleate (trade name: Atiprimod)
Treatment of multiple myeloma
Date designated: 12/2/2003
Callisto Pharmaceuticals, Inc.
2 Executive Drive, Suite 450
Sormerset, NJ 08873
INO-4995
Treatment of cystic fibrosis
Date designated: 8/15/2003
Inologic, Inc.
101 Elliott Ave. West
Seattle, WA 98119
TH9402 (trade name: Theralux Irradiation Device)
Treatment of chronic myelogenous leukemia (CML)
Date designated: 4/10/2003
Celmed BioSciences Inc.
2310 Alfred-Nobel Blvd.
Saint-Laurent (Quebec)
Canada H4S 2A4
5,5',5"-[Phosphinothioylidyne-tris(imino-2,1-ethanediyl)]tris[5-methylchelidoninium]trihydroide hexahydrochloride
Treatment of pancreatic cancer
Date designated: 8/20/2003
Now Pharm AG
241, route d'Arlon
L-1150
a-(3-aminophthalimido) (trade name: Actimid)
Treatment of multiple myeloma (See article: The Return of Thalidomide)
Date designated: 1/15/2003
Celgene Corporation
7 Powder Horn Drive
Warren, NJ 07059
a-galactosidase A (trade name: Plant-Produced Human a-Galactosidase)
Treatment of Fabry disease
Date designated: 1/21/2003
Large Scale Biology Corporation
3333 Vacaville Parkway, Suite 1000
Vacaville, CA 95688
ACA125
Treatment of epithelial ovarian cancer
Date designated: 11/25/2003
CellControl Biomedical Laboratories AG
Am Klopferspitz 19
82152 Martinsried (bei München)
alendronate (trade name: Fosamax)
Treatment of osteogenesis imperfecta in children 4 years of age and older
Date designated: 3/31/2003
Merck & Co., Inc.
126 East Lincoln Ave.
Rahway, NJ 07065-0900
alteplase (trade name: Activase)
Treatment of intraventricular hemorrhage
Date designated: 1/27/2003
Daniel F. Hanley, MD
Johns Hopkins University
600 N. Wolfe Street, Jefferson 1-109
Baltimore, MD 21287
AMG 531
Treatment of immune thrombocytopenic purpura (ITP)
Date designated: 3/27/2003
Amgen, Inc.
One Amgen Center Drive
Thousand Oaks, CA 91320-1799
anti-CD23 IgG1, kappa monoclonal antibody
Treatment of chronic lymphocytic leukemia (CLL)
Date designated: 2/12/2003
IDEC Pharmaceuticals, Inc.
3030 Callan Road
San Diego, CA 92121
anti-CEA sheep-human chimeric monoclonal antibody
Treatment of pancreatic cancer
Date designated: 5/21/2003
KS Biomedix Ltd.
1 Occam Court
The Surrey Research Park
Guildford
Surrey
GU2 7HJ
anti-interferon-gamma Fab from goats
Treatment of immunologic corneal graft rejection
Date designated: ?
Advanced Biotherapy, Inc.
6355 Topanga Canyon Blvd., Suite 510
Woodland Hills, CA 91367
antisense 20-mer phosphorothioate oligonucleotide (trade name: GTI-2040)
Treatment of renal cell carcinoma
Date designated: 3/12/2003
Lorus Therapeutics, Inc.
2 Meridian Road
Toronto, Ontario
Canada, M9W 4Z7
arsenic trioxide (trade name: Trisenox)
Treatment of chronic lymphocytic leukemia (CLL)
Date designated: 5/13/2003
Also: Treatment of liver cancer
Date designated: 6/13/2003
Cell Therapeutics, Inc.
501 Elliott Avenue West, Suite 400
Seattle, WA 98119
atomoxetine hydrochloride (trade name: Strattera)
Treatment of Tourette syndrome
Date designated: 8/26/2003
Eli Lilly & Company
Lily Corporate Center
Indianapolis, IN 46285
baclofen
Treatment of dystonia
Date designated: 12/2/2003
Medtronic Neurological
710 Medtronic Parkway NE
Minneapolis, MN 55432-5604
bifidobacterium longum infantis
Treatment of pediatric Crohn's disease
Date designated: 1/16/2003
Alimentary Health
Guardwell, Kinsale
Co. Cork, Ireland
