Most cases of acromegaly are caused by a growth hormone-secreting tumor of the pituitary gland in the brain. Surgery is usually done to remove as much of the tumor as possible, and often medications such as octreotide (Sandostatin) are given to shrink the tumor. Researchers at Federico II University of Naples in Italy studied 86 individuals with acromegaly who were given medication before and after undergoing partial removal (resection) of their pituitary tumors. They found that resection of at least 75% of the hormone-secreting tumor enhanced the response to medication. The research was published in the January 2006 issue of Journal of Clinical Endocrinology & Metabolism.
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