Rett syndrome protein binding detailed

Researchers at the University of Edinburgh have discovered that the protein associated with Rett syndrome, MeCP2, only binds to genes with a specific sequence of nucleotide bases. This means that identifying the potential binding sites can help identify genes that are regulated by the gene MECP2, which produces the MeCP2 protein. To date, the genes DLX5 and BDNF have emerged as strong MeCP2 target candidates and may be implicated in the Rett syndrome disease process. The research was published in the September 2005 issue of Molecular Cell.